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@Article{MarcianoWaLoTrSoSi:2011:ThAsFi,
               author = "Marciano, Fernanda Roberta and Wachesk, Cristiane da Costa and 
                         Lobo, Anderson de Oliveira and Trava-Airoldi, Vladimir Jesus and 
                         Soares, Cristina Pacheco and Silva, Newton Soares da",
          affiliation = "Laboratorio de Nanotecnologia Biomedica (NanoBio), Universidade do 
                         Vale do Paraiba (Univap), Av. Shishima Hifumi 2911, Sao Jose dos 
                         Campos, SP 12244-000, Brazil and Laborato´rio de Biologia Celular 
                         e Tecidual, Universidade do Vale do Paraiba (Univap), Av. Shishima 
                         Hifumi 2911, Sao Jose dos Campos, SP 12244-000, Brazil and 
                         Laboratorio de Nanotecnologia Biomedica (NanoBio), Universidade do 
                         Vale do Paraiba (Univap), Av. Shishima Hifumi 2911, Sao Jose dos 
                         Campos, SP 12244-000, Brazil and {Instituto Nacional de Pesquisas 
                         Espaciais (INPE)} and Laborato´rio de Biologia Celular e Tecidual, 
                         Universidade do Vale do Paraiba (Univap), Av. Shishima Hifumi 
                         2911, Sao Jose dos Campos, SP 12244-000, Brazil",
                title = "Thermodynamic aspects of fibroblastic spreading on diamond-like 
                         carbon films containing titanium dioxide nanoparticles",
              journal = "Theoretical Chemistry Accounts",
                 year = "2011",
               volume = "130",
               number = "4-6",
                pages = "1085--1093",
                month = "Dec.",
             keywords = "Cell spreading, Cellular viability, Diamond-like carbon, 
                         Hydrophilicity, TiO2 nanoparticles, Work of adhesion.",
             abstract = "The combination of low friction, wear resistance, high hardness, 
                         biocompatibility, and chemical inertness makes diamond-like carbon 
                         (DLC) films suitable in numerous applications in biomedical 
                         engineering. The cytotoxicity of DLC films containing TiO2 
                         nanoparticles was practical and theoretically evaluated. The films 
                         were grown on 316L stainless steel substrates from a dispersion of 
                         TiO2 nanopowder in hexane. Raman spectroscopy shows that the 
                         presence of TiO2 increased the graphite-like bonds in the films. 
                         The incorporation of TiO2 nanoparticles into DLC films increases 
                         surface roughness, decreases water contact angle (increased 
                         hydrophilic character), and increases the total free surface 
                         energy due to the higher polar component. As the concentration of 
                         TiO2 increased, the films increased the cell viability (MTT 
                         assay), becoming more thermodynamically favorable to cell 
                         spreading (DFAdh values became more negative). This was evidenced 
                         through the increasing number of projections (philopodia and 
                         lamellipodia), indicating a higher adhesion between the L929 cells 
                         and the films. The practical and theoretical findings of this 
                         study show that the incorporation of TiO2 into DLC films is 
                         effective in enhancing cell viability. These results show the 
                         potential use of DLC and TiO2-DLC films in biomedical 
                         applications.",
                  doi = "10.1007/s00214-011-1018-5",
                  url = "http://dx.doi.org/10.1007/s00214-011-1018-5",
                 issn = "1432-881X",
                label = "lattes: 3455204481678421 5 MarcianoMaWaLoTrSoSi:2011:ThAsOf",
             language = "en",
           targetfile = "marciano1.pdf",
        urlaccessdate = "23 jan. 2021"
}


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