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@Article{ZaninMaSiMaCoLo:2014:GrCaNa,
               author = "Zanin, Hudson and Margraf-Ferreira, A. and Silva, N. S. Da and 
                         Marciano, F. R. and Corat, Evaldo Jose and Lobo, A. O.",
          affiliation = "{Instituto Nacional de Pesquisas Espaciais (INPE)} and Laboratory 
                         of Cell Biology and Tissue, Institute of Research and Development, 
                         University of Vale Do Paraiba, Av. Shishima Hifumi, 2911, CEP: 
                         12244-000 Sao Jose dos Campos, SP, Brazil and Laboratory of Cell 
                         Biology and Tissue, Institute of Research and Development, 
                         University of Vale Do Paraiba, Av. Shishima Hifumi, 2911, CEP: 
                         12244-000 Sao Jose dos Campos, SP, Brazil and Laboratory of 
                         Biomedical Nanotechnology, Institute of Research and Development, 
                         University of Vale Do Paraiba, Av. Shishima Hifumi, 2911, CEP: 
                         12244-000 Sao Jose dos Campos, SP, Brazil and {Instituto Nacional 
                         de Pesquisas Espaciais (INPE)} and Laboratory of Biomedical 
                         Nanotechnology, Institute of Research and Development, University 
                         of Vale Do Paraiba, Av. Shishima Hifumi, 2911, CEP: 12244-000 Sao 
                         Jose dos Campos, SP, Brazil",
                title = "Graphene and carbon nanotube composite enabling a new prospective 
                         treatment for trichomoniasis disease",
              journal = "Materials Science and Engineering C",
                 year = "2014",
               volume = "41",
                pages = "65--69",
                month = "Aug.",
             keywords = "graphene oxide, carbon nanotube oxide, composite, Tritrichomonas 
                         foetus, drug carrier.",
             abstract = "We report the synthesis and application of novel graphene oxide 
                         and carbon nanotube oxide (GCN-O) composite. First, pristine 
                         multi-walled carbon nanotube was prepared by chemical vapour 
                         deposition furnace and then exfoliated and oxidised simultaneously 
                         by oxygen plasma etching. The superficial and volumetric 
                         compositions of GCN-O were measured by XPS spectroscopy and EDX 
                         spectroscopy, respectively. Both XPS and EDX analyses evidence 
                         that the GCN-O is composed of up to 20% of oxygen atoms. As a 
                         result, GCN-O forms a stable colloidal aqueous solution and shows 
                         to have strong interaction with the cell membrane of 
                         Tritrichomonas foetus protozoa, making easy its application as a 
                         drug carrier. Trichomoniasis infection of cattle is a devastating 
                         disease for cattle producers, causing some damages to females and 
                         fetus, and the abortion is the most serious result of this 
                         disease. There is no effective treatment for trichomoniasis 
                         infection yet. Therefore, new treatment, especially one with no 
                         collateral effects in animals, is required. With this goal in 
                         mind, our results suggest that water dispersible composite is a 
                         novel nanomaterial, promising for Trichomoniasis infection 
                         treatment and as therapeutic delivery agent as well.",
                  doi = "10.1016/j.msec.2014.04.020",
                  url = "http://dx.doi.org/10.1016/j.msec.2014.04.020",
                 issn = "0928-4931",
                label = "scopus 2014-05 ZaninMaDaMaCoLo:2014:GrCaNa",
             language = "en",
           targetfile = "1-s2.0-S0928493114002124-main.pdf",
        urlaccessdate = "05 dez. 2020"
}


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