author = "Bock, Eduardo Guy Perp{\'e}tuo and S{\'a}, Rosa Correa Leoncio 
                         de and Rakebrandt, Jan-Hendric and Trava-Airoldi, Vladimir Jesus 
                         and Andrade, Aron",
          affiliation = "{} and {Instituto Nacional de Pesquisas Espaciais (INPE)} and {} 
                         and {Instituto Nacional de Pesquisas Espaciais (INPE)}",
                title = "Laser surface modification and characterization of titanium for 
                         endothelialization of ventricular assist devices",
            booktitle = "Proceedings...",
                 year = "2019",
         organization = "KNMF User Meeting",
             abstract = "Ventricular Assist Devices (VAD) are pumps that stabilize 
                         hemodynamics of patients in end stage of congestive heart failure 
                         until their recovery or cardiac transplantation [1- 3]. Typically, 
                         titanium is the biomaterial chosen for machining processes of VADs 
                         because it provides stable biological integration without 
                         compromising implant biocompatibility. A promising scientific 
                         trend is to develop biofunctional materials that integrate with 
                         the surrounding endothelial cells that line the artery to afford a 
                         prohealing functional response [4, 5]. Biofunctional surfaces for 
                         VADs became possible through coatings and surface modification in 
                         order to improve the interface between biomaterial and assisted 
                         organ [6]. Our previous studies with Plasma Electrolytic Oxidation 
                         (PEO) technique formed a promising textured oxide layer with 
                         scaffolding characteristics and pore size proportional to 
                         endothelial cells of circulating blood [6, 7]. The textured layer 
                         created by PEO is capable of promoting endothelialization in vitro 
                         as shown with in vitro tests performed with Human Umbilical Vein 
                         Endothelial Cells (HUVEC) [7, 8]. The aim of the experiments is to 
                         promote a textured surface similar to that obtained by PEO process 
                         but using laser materials processing available in KNMF. Unlike 
                         micro arcs created in PEO [9, 10], the interaction of laser with 
                         metal surface can be controlled at micro and nano levels [11, 12]. 
                         Thus, we expect to alter morphology and topography, creating pores 
                         and scaffolds of size between 5 to 20 \μm increasing 
                         adhesion of endothelial cells and reducing hemolysis inside VADs 
  conference-location = "Karlsruhe, Germany",
      conference-year = "19-20 Feb.",
           targetfile = "Poster KNMF 2019 (1).pdf",
        urlaccessdate = "16 abr. 2021"