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@Article{AntoniniMSTVSCMM:2019:OsDiBo,
               author = "Antonini, Leonardo Marasca and Menezes, Tiago Lemes and Santos 
                         J{\'u}nior, Adilar Gon{\c{c}}alves dos and Takimi, Antonio 
                         Shigueaki and Villarinho, Denis Jardim and Santos, Bruno Paiva dos 
                         and Camassola, Melissa and Marcuzzo, Jossano Saldanha and 
                         Malfatti, C{\'e}lia de Fraga",
          affiliation = "{Universidade Federal do Rio Grande do Sul (UFRGS)} and 
                         {Universidade Federal do Rio Grande do Sul (UFRGS)} and 
                         {Universidade Federal do Rio Grande do Sul (UFRGS)} and 
                         {Universidade Federal do Rio Grande do Sul (UFRGS)} and 
                         {Universidade Feevale} and {University of Bordeaux} and 
                         {Universidade Luterana do Brasil} and {Instituto Nacional de 
                         Pesquisas Espaciais (INPE)} and {Universidade Federal do Rio 
                         Grande do Sul (UFRGS)}",
                title = "Osteogenic differentiation of bone marrow-derived mesenchymal stem 
                         cells on anodized niobium surface",
              journal = "Journal of Materials Science: Materials in Medicine",
                 year = "2019",
               volume = "30",
               number = "9",
                pages = "e104",
                month = "Sept.",
             abstract = "Currently, titanium and its alloys are the most used materials for 
                         biomedical applications. However, because of the high costs of 
                         these metals, new materials, such as niobium, have been 
                         researched. Niobium appears as a promising material due to its 
                         biocompatibility, and excellent corrosion resistance. In this 
                         work, anodized niobium samples were produced and characterized. 
                         Their capacity to support the osteogenic differentiation of bone 
                         marrow-derived mesenchymal stem cells (BM-MSCs) was also tested. 
                         The anodized niobium samples were characterized by SEM, 
                         profilometry, XPS, and wettability. BM-MSCs were cultured on the 
                         samples during 14 days, and tested for cell adhesion, metabolic 
                         activity, alkaline phosphatase activity, and mineralization. 
                         Results demonstrated that anodization promotes the formation of a 
                         hydrophilic nanoporous oxide layer on the Nb surface, which can 
                         contribute to the increase in the metabolic activity, and in 
                         osteogenic differentiation of BM-MSCs, as well as to the 
                         extracellular matrix mineralization.",
                  doi = "10.1007/s10856-019-6305-z",
                  url = "http://dx.doi.org/10.1007/s10856-019-6305-z",
                 issn = "0957-4530",
             language = "en",
           targetfile = "Antonini2019_Article_OsteogenicDifferentiationOfBon.pdf",
        urlaccessdate = "25 jan. 2021"
}


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