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@Article{BorgesNRLKTMMK:2019:CoAtPr,
               author = "Borges, Aline Chiodi and Nishime, Thalita Mayumi Castaldelli and 
                         Rovetta, Sabrina de Moura and Lima, Gabriela de Morais Gouv{\^e}a 
                         and Kostov, Konstantin Georgiev and Thim, Gilmar 
                         Patroc{\'{\i}}nio and Menezes, Beatriz Rossi Canuto de and 
                         Machado, Jo{\~a}o Paulo Barros and Koga-Ito, Cristiane Yumi",
          affiliation = "{Universidade Estadual Paulista (UNESP)} and {Universidade 
                         Estadual Paulista (UNESP)} and {Instituto Taubat{\'e} de Ensino 
                         Superior (ITES)} and {Instituto Taubat{\'e} de Ensino Superior 
                         (ITES)} and {Universidade Estadual Paulista (UNESP)} and 
                         {Instituto Tecnol{\'o}gico de Aeron{\'a}utica (ITA)} and 
                         {Instituto Tecnol{\'o}gico de Aeron{\'a}utica (ITA)} and 
                         {Instituto Nacional de Pesquisas Espaciais (INPE)} and {Instituto 
                         Taubat{\'e} de Ensino Superior (ITES)}",
                title = "Cold atmospheric pressure plasma jet reduces trichophyton rubrum 
                         adherence and infection capacity",
              journal = "Mycapathologia",
                 year = "2019",
               volume = "184",
               number = "5",
                pages = "585--595",
                month = "Oct.",
             keywords = "Cold plasma, Onychomycosis, Trichophyton rubrum, Antifungal 
                         agents.",
             abstract = "This study aimed to evaluate the effects of cold atmospheric 
                         pressure plasma (CAPP) jet on Trichophyton rubrum growth, 
                         germination and adherence to nail. The effects of plasma jet on T. 
                         rubrum conidia germination and on mycelial growth were evaluated 
                         by in vitro assays. An ex vivo nail infection model was used to 
                         evaluate the effects on conidia adherence and infection. 
                         Biochemical analyses of nail fragments exposed or not to CAPP were 
                         performed by attenuated total reflectance-Fourier transform 
                         infrared (ATR-FTIR) spectroscopy. Plasma jet exposure for 10 and 
                         15 min completely inhibited mycelial growth after only one 
                         exposure. Fifteen minutes of exposure could reduce conidia 
                         germination in suspension. Fungal suspensions exposed to plasma 
                         jet for 10 and 15 min were not able to infect nail specimens. 
                         These results were corroborated by ATR-FTIR analyses of nail 
                         fragments. In conclusion, single exposure to CAPP for 15 min was 
                         able to inhibit fungal growth, adherence and infection capacity. 
                         The results suggest that cold atmospheric plasma jet can be a 
                         promising alternative for the treatment of onychomycoses caused by 
                         T. rubrum.",
                  doi = "10.1007/s11046-019-00375-2",
                  url = "http://dx.doi.org/10.1007/s11046-019-00375-2",
                 issn = "0301-486X",
             language = "en",
           targetfile = "borges_cold.pdf",
        urlaccessdate = "11 abr. 2021"
}


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