@Article{PessoaSCDFRTFMLM:2017:PrEfC.,
author = "Pessoa, R. S. and Santos, V. P. dos and Cardoso, S. B. and Doria,
A. C. O. C. and Figueira, F. R. and Rodrigues, B. V. M. and
Testoni, G. E. and Fraga, Mariana Amorim and Marciano, F. R. and
Lobo, A. O. and Maciel, H. S.",
affiliation = "{Universidade do Vale do Para{\'{\i}}ba (UNIVAP)} and
{Universidade do Vale do Para{\'{\i}}ba (UNIVAP)} and
{Universidade Brasil} and {Universidade do Vale do
Para{\'{\i}}ba (UNIVAP)} and {Universidade do Vale do
Para{\'{\i}}ba (UNIVAP)} and {Universidade Brasil} and
{Instituto Tecnol{\'o}gico de Aeron{\'a}utica (ITA)} and
{Instituto Nacional de Pesquisas Espaciais (INPE)} and
{Universidade Brasil} and {Universidade Brasil} and {Universidade
do Vale do Para{\'{\i}}ba (UNIVAP)}",
title = "TiO2 coatings via atomic layer deposition on polyurethane and
polydimethylsiloxane substrates: properties and effects on C.
albicans growth and inactivation process",
journal = "Applied Surface Science",
year = "2017",
volume = "422",
pages = "73--84",
month = "Nov.",
keywords = "Atomic layer deposition, Titanium dioxide, Polyurethane,
Polydimethylsiloxane, Candida albicans, Fungistatic effect, Fungal
inactivation.",
abstract = "Atomic layer deposition (ALD) surges as an attractive technology
to deposit thin films on different substrates for many advanced
biomedical applications. Herein titanium dioxide (TiO2) thin films
were successful obtained on polyurethane (PU) and
polydimethylsiloxane (PDMS) substrates using ALD. The effect of
TiO2 films on Candida albicans growth and inactivation process
were also systematic discussed. TiCl4 and H2O were used as
precursors at 80 °C, while the reaction cycle number ranged from
500 to 2000. Several chemical, physical and physicochemical
techniques were used to evaluate the growth kinetics, elemental
composition, material structure, chemical bonds, contact angle,
work of adhesion and surface morphology of the ALD TiO2 thin films
grown on both substrates. For microbiological analyses, yeasts of
standard strains of C. albicans were grown on non- and TiO2-coated
substrates. Next, the antifungal and photocatalytic activities of
the TiO2 were also investigated by counting the colony-forming
units (CFU) before and after UV-light treatment. Chlorine-doped
amorphous TiO2 films with varied thicknesses and Cl concentration
ranging from 2 to 12% were obtained. In sum, the ALD TiO2 films
suppressed the yeast-hyphal transition of C. albicans onto PU,
however, a high adhesion of yeasts was observed. Conversely, for
PDMS substrate, the yeast adhesion did not change, as observed in
control. Comparatively to control, the TiO2-covered PDMS had a
reduction in CFU up to 59.5% after UV treatment, while no
modification was observed to TiO2-covered PU. These results
pointed out that ALD chlorine-doped amorphous TiO2 films grown on
biomedical polymeric surfaces may act as fungistatic materials.
Furthermore, in case of contamination, these materials may also
behave as antifungal materials under UV light exposure.",
doi = "10.1016/j.apsusc.2017.05.254",
url = "http://dx.doi.org/10.1016/j.apsusc.2017.05.254",
issn = "0169-4332",
language = "en",
targetfile = "pessoa_ti.pdf",
urlaccessdate = "26 abr. 2024"
}