@Article{BorgesNRLKTMMK:2019:CoAtPr,
author = "Borges, Aline Chiodi and Nishime, Thalita Mayumi Castaldelli and
Rovetta, Sabrina de Moura and Lima, Gabriela de Morais Gouv{\^e}a
and Kostov, Konstantin Georgiev and Thim, Gilmar
Patroc{\'{\i}}nio and Menezes, Beatriz Rossi Canuto de and
Machado, Jo{\~a}o Paulo Barros and Koga-Ito, Cristiane Yumi",
affiliation = "{Universidade Estadual Paulista (UNESP)} and {Universidade
Estadual Paulista (UNESP)} and {Instituto Taubat{\'e} de Ensino
Superior (ITES)} and {Instituto Taubat{\'e} de Ensino Superior
(ITES)} and {Universidade Estadual Paulista (UNESP)} and
{Instituto Tecnol{\'o}gico de Aeron{\'a}utica (ITA)} and
{Instituto Tecnol{\'o}gico de Aeron{\'a}utica (ITA)} and
{Instituto Nacional de Pesquisas Espaciais (INPE)} and {Instituto
Taubat{\'e} de Ensino Superior (ITES)}",
title = "Cold atmospheric pressure plasma jet reduces trichophyton rubrum
adherence and infection capacity",
journal = "Mycapathologia",
year = "2019",
volume = "184",
number = "5",
pages = "585--595",
month = "Oct.",
keywords = "Cold plasma, Onychomycosis, Trichophyton rubrum, Antifungal
agents.",
abstract = "This study aimed to evaluate the effects of cold atmospheric
pressure plasma (CAPP) jet on Trichophyton rubrum growth,
germination and adherence to nail. The effects of plasma jet on T.
rubrum conidia germination and on mycelial growth were evaluated
by in vitro assays. An ex vivo nail infection model was used to
evaluate the effects on conidia adherence and infection.
Biochemical analyses of nail fragments exposed or not to CAPP were
performed by attenuated total reflectance-Fourier transform
infrared (ATR-FTIR) spectroscopy. Plasma jet exposure for 10 and
15 min completely inhibited mycelial growth after only one
exposure. Fifteen minutes of exposure could reduce conidia
germination in suspension. Fungal suspensions exposed to plasma
jet for 10 and 15 min were not able to infect nail specimens.
These results were corroborated by ATR-FTIR analyses of nail
fragments. In conclusion, single exposure to CAPP for 15 min was
able to inhibit fungal growth, adherence and infection capacity.
The results suggest that cold atmospheric plasma jet can be a
promising alternative for the treatment of onychomycoses caused by
T. rubrum.",
doi = "10.1007/s11046-019-00375-2",
url = "http://dx.doi.org/10.1007/s11046-019-00375-2",
issn = "0301-486X",
language = "en",
targetfile = "borges_cold.pdf",
urlaccessdate = "26 abr. 2024"
}