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		<doi>10.1007/s10856-021-06596-6</doi>
		<issn>0957-4530</issn>
		<citationkey>WacheskSeSaTrLoMa:2021:ViBiDi</citationkey>
		<title>In vivo biocompatibility of diamond-like carbon films containing TiO2 nanoparticles for biomedical applications</title>
		<year>2021</year>
		<month>Sept.</month>
		<typeofwork>journal article</typeofwork>
		<secondarytype>PRE PI</secondarytype>
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		<author>Wachesk, C. C.,</author>
		<author>Seabra, S. H.,</author>
		<author>Santos, T. A. T. dos,</author>
		<author>Trava-Airoldi, Vladimir Jesus,</author>
		<author>Lobo, Anderson de Oliveira,</author>
		<author>Marciano, F. R.,</author>
		<orcid>0000-0001-7740-8766</orcid>
		<group></group>
		<group></group>
		<group></group>
		<group>COPDT-CGIP-INPE-MCTI-GOV-BR</group>
		<affiliation>Universidade Federal de São Paulo (UNIFESP)</affiliation>
		<affiliation>Universidade Estadual da Zona Oeste (UEZO)</affiliation>
		<affiliation>Universidade Estadual da Zona Oeste (UEZO)</affiliation>
		<affiliation>Instituto Nacional de Pesquisas Espaciais (INPE)</affiliation>
		<affiliation>Universidade Federal do Piaui (UFPI)</affiliation>
		<affiliation>Universidade Federal do Piaui (UFPI)</affiliation>
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		<electronicmailaddress>marciano@ufpi.edu.br</electronicmailaddress>
		<journal>Journal of Materials Science: Materials in Medicine</journal>
		<volume>32</volume>
		<number>9</number>
		<pages>e117</pages>
		<secondarymark>A1_MATERIAIS A1_INTERDISCIPLINAR A1_ENGENHARIAS_IV A1_ENGENHARIAS_II A2_ODONTOLOGIA A2_MEDICINA_VETERINÁRIA A2_ARQUITETURA_E_URBANISMO B1_QUÍMICA B1_MEDICINA_II B1_MEDICINA_I B1_FARMÁCIA B1_ENGENHARIAS_III B1_CIÊNCIAS_BIOLÓGICAS_II B1_CIÊNCIAS_BIOLÓGICAS_I B1_BIOTECNOLOGIA B1_ASTRONOMIA_/_FÍSICA B2_EDUCAÇÃO_FÍSICA B2_CIÊNCIAS_BIOLÓGICAS_III C_CIÊNCIA_DE_ALIMENTOS</secondarymark>
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		<abstract>Hybrid diamond-like carbon (DLC) with incorporated titanium dioxide (TiO2) nanoparticle coatings have low friction coefficient, high wear resistance, high hardness, biocompatibility, and high chemical stability. They could be employed to modify biomedical alloys surfaces for numerous applications in biomedical engineering. Here we investigate for the first time the in vivo inflammatory process of DLC coatings with incorporated TiO2 nanoparticles. TiO2-DLC films were grown on AISI 316 stainless-steel substrates using plasma-enhanced chemical vapor deposition. The coated substrates were implanted in CF1 mice peritoneum. The in vivo cytotoxicity and biocompatibility of the samples were analyzed from macrophage lavage. Analysis in the first weeks after implantation could be helpful to evaluate the acute cytotoxicity generated after a possible inflammatory process. The in vivo results showed no inflammatory process. A significant increase in nitric oxide production on the uncoated substrates was confirmed through cytometry, and the coated substrates demonstrated biocompatibility. The presence of TiO2 nanoparticles enhanced the wound healing activity, due to their astringent and antimicrobial properties. DLC and TiO2-DLC coatings were considered biocompatible, and the presence of TiO2 nanoparticles reduced the inflammatory reactions, increasing DLC biocompatibility.</abstract>
		<area>FISMAT</area>
		<language>en</language>
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