@Article{WacheskSeSaTrLoMa:2021:ViBiDi,
               author = "Wachesk, C. C. and Seabra, S. H. and Santos, T. A. T. dos and 
                         Trava-Airoldi, Vladimir Jesus and Lobo, Anderson de Oliveira and 
                         Marciano, F. R.",
          affiliation = "{Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Estadual da Zona Oeste (UEZO)} and {Universidade 
                         Estadual da Zona Oeste (UEZO)} and {Instituto Nacional de 
                         Pesquisas Espaciais (INPE)} and {Universidade Federal do Piaui 
                         (UFPI)} and {Universidade Federal do Piaui (UFPI)}",
                title = "In vivo biocompatibility of diamond-like carbon films containing 
                         TiO2 nanoparticles for biomedical applications",
              journal = "Journal of Materials Science: Materials in Medicine",
                 year = "2021",
               volume = "32",
               number = "9",
                pages = "e117",
                month = "Sept.",
             abstract = "Hybrid diamond-like carbon (DLC) with incorporated titanium 
                         dioxide (TiO2) nanoparticle coatings have low friction 
                         coefficient, high wear resistance, high hardness, 
                         biocompatibility, and high chemical stability. They could be 
                         employed to modify biomedical alloys surfaces for numerous 
                         applications in biomedical engineering. Here we investigate for 
                         the first time the in vivo inflammatory process of DLC coatings 
                         with incorporated TiO2 nanoparticles. TiO2-DLC films were grown on 
                         AISI 316 stainless-steel substrates using plasma-enhanced chemical 
                         vapor deposition. The coated substrates were implanted in CF1 mice 
                         peritoneum. The in vivo cytotoxicity and biocompatibility of the 
                         samples were analyzed from macrophage lavage. Analysis in the 
                         first weeks after implantation could be helpful to evaluate the 
                         acute cytotoxicity generated after a possible inflammatory 
                         process. The in vivo results showed no inflammatory process. A 
                         significant increase in nitric oxide production on the uncoated 
                         substrates was confirmed through cytometry, and the coated 
                         substrates demonstrated biocompatibility. The presence of TiO2 
                         nanoparticles enhanced the wound healing activity, due to their 
                         astringent and antimicrobial properties. DLC and TiO2-DLC coatings 
                         were considered biocompatible, and the presence of TiO2 
                         nanoparticles reduced the inflammatory reactions, increasing DLC 
                         biocompatibility.",
                  doi = "10.1007/s10856-021-06596-6",
                  url = "http://dx.doi.org/10.1007/s10856-021-06596-6",
                 issn = "0957-4530",
             language = "en",
           targetfile = "washesc_in vivo.pdf",
        urlaccessdate = "11 maio 2024"
}